H.sapiens ---------------------------------MPYSVGF-----READAATSFLRAARS P.troglodytes ---------------------------------MPYSVGF-----READAATSFLRAARS M.mulatta MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRK-----KKADAATSFLRAARS M.musculus MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRK-----KKADAATSFLRAARS B.taurus ---------------------------------MPYSNGR-----RTADAATSFLRAARS C.lupus --------------------------------------MA-----AMADAATSFLRAARS G.gallus MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKVSDAGADAATSFLRAARS R.norvegicus -----------------------------MAERPRRSGSD-----PAADAATSFLRAARS D.rerio MAQAAKQIRKNKDLQELAAQELREKEEEKIKKRNRSRDRR-----RKADATTSFLRAARS S.cerevisiae ------------------------------------------------------------ A.thaliana MT--------------------------VFSGRQV------VPMDYEAEVSQRLLEAILD O.sativa -----------------------------MSRRRAAAVAAAAREEEEASPAQRLVEAALR H.sapiens GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV---------KMVVELLHKEIILET P.troglodytes GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV---------KMVVELLHKEIILET M.mulatta GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV---------KMVVELLHKEIILET M.musculus GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV---------KMVVELLHKEIILET B.taurus GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV---------KMVVELLHKEIILET C.lupus GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV---------KMVVELLHKEIILET G.gallus GNLDRALDHLRNGVDINTCNQNGLNALHLASKEGHT---------KMVVELLHKEIVLET R.norvegicus GNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV---------KMVVELLHKEIILET D.rerio GNLEKALDHIKNGIDINIANQNGLNGLHLASKEGHV---------KMVLELLHNGIDLET S.cerevisiae ------------------------------------------------------------ A.thaliana GDFKTASDCVSD-------------PLVDVNFVGAVSLKTRRSEVVLRDESPSEVRVEYE O.sativa GDVVTMEACLAAAAAAAAADDDTDDGVPAASRVGVARLRVRCAEVALREEAAGEVIVESR H.sapiens TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN P.troglodytes TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN M.mulatta TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN M.musculus TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN B.taurus TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN C.lupus TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN G.gallus TTKKGNTALHIAALAGQQDVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN R.norvegicus TTK--------------------------------------------------------- D.rerio TTKKGNTALHIAALAGQEKVVAELINYGANVNAQSQKGFSPLYMAAQENHLEVVKYLLEH S.cerevisiae ------------------------------------------------------------ A.thaliana EFKTDVTALFLAVNFGNAALVKELLNIGADVNQKLFRGFATT-VAVREGHFDVFEILLKA O.sativa ELKTDVSPLFAAAHAGHAEVVRTLLVAGADVNQKLFLGYATT-AAAREGNIHILEMLLQA H.sapiens GANQNVATED--------------------------GFTPLAVALQQGHENVVAHLINYG P.troglodytes GANQNVATED--------------------------GFTPLAVALQQGHENVVAHLINYG M.mulatta GANQNVATED--------------------------GFTPLAVALQQGHENVVAHLINYG M.musculus GANQNVATED--------------------------GFTPLAVALQQGHENVVAHLINYG B.taurus GANQNVATED--------------------------GFTPLAVALQQGHENVVAHLINYG C.lupus GANQNVATED--------------------------GFTPLAVALQQGHENVVAHLINYG G.gallus GANQNVATED--------------------------GFTPLAVALQQGHENVVAHLINYG R.norvegicus -------VRD--------------------------GFTPLAVALQQGHENVVAHLINYG D.rerio GANQSLPTED--------------------------GFTPLAVALQQGHENVVALLINYG S.cerevisiae ---------------------------------------------------MVNELENVP A.thaliana GASQPACEEALVGASCHGRSRFVELLMGTDLIRPQVAVHALATACCRGFVDVVGTLLKCG O.sativa GVTREACEDSLSEAALFAEAEAVRLLVCSEMIQPEAAAHALVTASSRGFDDVVVILLQNG :* * : H.sapiens TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNPDVLSK------ P.troglodytes TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNPDVLSK------ M.mulatta TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNPDVLSK------ M.musculus TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNPDVLSK------ B.taurus TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNPDVLSK------ C.lupus TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTRFEPL G.gallus TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNADVLSK------ R.norvegicus TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNPDVLSK------ D.rerio TKGKV-----------------RLPALHIAARNDDTRTAAVLLQNDPNPDVLSK------ S.cerevisiae --------------RASTLTNEEQ---TVDPSNNDSQ-EDISLGD--SNEITSLASLKAI A.thaliana VDANSTDRLLLQSSKPSLYTNVDCTALVAAIVNRQVSAVRVLLQAGVKTDIMVRLGAWSW O.sativa VDVNSMARVLLRSVKPALHANVNCTPLVAAVMSRQISTVKLLIEEGSYLDCLVQVGSWCW . : : : : H.sapiens ------------------TGFTPLHIAAHYEN--LNVAQ---LLLNRGAS--VNFTPQNG P.troglodytes ------------------TGFTPLHIAAHYEN--LNVAQ---LLLNRGAS--VNFTPQNG M.mulatta ------------------TGFTPLHIAAHYEN--LNVAQ---LLLNRGAS--VNFTPQNG M.musculus ------------------TGFTPLHIAAHYEN--LNVAQ---LLLNRGAS--VNFTPQNG B.taurus ------------------TGFTPLHIAAHYEN--LNVAQ---LLLNRGAS--VNFTPQNG C.lupus MNAKGNVLGVEQ-----ETGFTPLHIAAHYEN--LNVAQ---LLLNRGAS--VNFTPQNG G.gallus ------------------TGFTPLHIAAHYEN--LSVAQ---LLLNRGAS--VNFTPQNG R.norvegicus ------------------TGFTPLHIAAHYEN--LNVAQ---LLLNRGAS--VNFTPQNG D.rerio ------------------TGFTPLHIAAHYEN--LSVAQ---LLLNRGAN--VNFTPKNG S.cerevisiae RSGNEEESGNEQVNHNDEAEEDPLLTRYHTACQRGDLATVKEMIHGKLLEVNNDGDSTEH A.thaliana DTNTGEEFRVGA---GVAEPYPLTWCAVEYFETSGDILR---LLLKLQS----PNALHNG O.sativa DSATGEELRVGA---CLGEKYNAIWCAVEYYECSGEILK---LLLDKAPW--LLETPRKG . .: :: : H.sapiens ITPLHIASRRGNVIMVRLLLDRGAQIETKT-----KDELTPLHCAARNGHVRISEILLDH P.troglodytes ITPLHIASRRGNVIMVRLLLDRGAQIETKT-----KDELTPLHCAARNGHVRISEILLDH M.mulatta ITPLHIASRRGNVIMVRLLLDRGAQIETKT-----KDELTPLHCAARNGHVRISEILLDH M.musculus ITPLHIASRRGNVIMVRLLLDRGAQIETRT-----KDELTPLHCAARNGHVRISEILLDH B.taurus ITPLHIASRRGNVIMVRLLLDRGAQIETRT-----KDELTPLHCAARNGHLRISEILLDH C.lupus ITPLHIASRRGNVIMVRLLLDRGAQIETRT-----KDELTPLHCAARNGHVRISEILLDH G.gallus ITPLHIASRRGNIIMVRLLLDRGAQIETRT-----KDELTPLHCAARNGHVRIAEILLDH R.norvegicus ITPLHIASRRGNVIMVRLLLDRGAQIETRT-----KDELTPLHCAARNGHVRISEILLDH D.rerio ITPLHIASRRGNVIMVRLLLDRGAQIDAKT-----KDELTPLHCAARNGHVRVVEILLDQ S.cerevisiae ITGLHWASINNRLSVVDFLVSQGADVNARA----GALH---------------------- A.thaliana RTLLHHAVLCGNKAAVSVLLDCGADPEAPIKTSRGIEL-RPIHIAARDGSVEIIQQLVGF O.sativa RNLLCHAILCQNPNAVSVLLNAGANPRFPIMMTNGTHVSYPIHFAARLGHAPVLKQLMLD . * * . * .*:. **: H.sapiens GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA----HCGH P.troglodytes GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA----HCGH M.mulatta GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA----HCGH M.musculus GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAA----HCGH B.taurus GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAA----HCGH C.lupus GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAA----HCGH G.gallus GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYSAEIDDITLDHLTPLHVAA----HCGH R.norvegicus GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAA----HCGH D.rerio GAPLQAKTKNGLSPIHMAAQGDHMDCVRQLLQYNAEIDDITLDHLTPLHVAA----HCGH S.cerevisiae ------------------------------------------------------------ A.thaliana GCDINSKNDVGNTALLISIKHKHPECVKVLALDGADFGLVNKFGHSAVSIAESNKWSLGL O.sativa GANINAQTSTGDTPLMVSARCGHSDCFLELIKSGADLGIVNNAGDTAIMLAKKSSFSSTI H.sapiens HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK-TGASIDAVTESGLTPLH P.troglodytes HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK-TGASIDAVTESGLTPLH M.mulatta HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK-TGASIDAVTESGLTPLH M.musculus HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLK-TGASIDAVTESGLTPLH B.taurus HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLK-MGASIDAVTESGLTPLH C.lupus HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLK-TGASIDAVTESGLTPLH G.gallus HRVAKLLVEKGAKPNSRALNGFTPLHIACKKNHIRVMELLLK-TGASIDAVTESGLTPLH R.norvegicus HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLK-TGASIDAVTE------- D.rerio HRMVKVLLDKGAKANARALNGFTPLHIACKKNHMRSMDLLLK-HSASLEAVTESGLTPLH S.cerevisiae -------------------------------------------------------ATPLH A.thaliana ERVILELIRFGVVPHSSNASVFSPLLYGAQAGDAEALKALVKAQDIYLDYQDEEGFSAAM O.sativa IDILSRALSCGGCITSSDITVFSPLHFFAASDSAEALLMTLHYSAADLNRPDGSGLTPVM H.sapiens VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA--RAGHTE-VAKYLL----QNK-A P.troglodytes VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA--RAGHTE-VAKYLL----QNK-A M.mulatta VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA--RAGHTE-VAKYLL----QNK-A M.musculus VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA--RAGHTE-VAKYLL----QNK-A B.taurus VASFMGHLPIVKSLLQREASPNVSNVKVETPLHMAA--RAGHTE-VAKYLL----QNK-A C.lupus VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA--RAGHTE-VAKYLL----QNK-A G.gallus VAAFMGHLPIVKTLLQRGASPNVSNVKVETPLHMAA--RAGHMD-VAKYLI----QNK-A R.norvegicus --------------------------KVETPLHMAA--RAGHTE-VAKYLL----QNK-A D.rerio VAAFMGHLNIVKSLLQRGASPNASNVKVETPLHMAA--RAGHCE-VAQFLL----QNN-A S.cerevisiae WAARYGYVYIVDFLLKHGADPTMTDDQGFNLLHLSVNS--SNIM-LVLYVLFNVVSKGLL A.thaliana LAAMNGHVEAFRVLVYAGADVKLYNNSGDTVVSLSE--QNGNRDVIEKVML----EFALE O.sativa VAAESGHADIFRLLVMAGADIAATSAEGKSAMSIIRSRAPETRDRFEQILL----QASLA . . : : . :: . H.sapiens KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA P.troglodytes KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA M.mulatta KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA M.musculus KANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALA B.taurus KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETALA C.lupus KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGQVETALA G.gallus KINAKAKDDQTPLHCAARIGHTSMVQLLLENNADPNLATTAGHTPLHIAAREGHVDTALA R.norvegicus KANAKAKDDQTPLHCAARIGHTSMVKLLLENDASPNLATTAGHTPLHTAAREGHVDTALA D.rerio QVDAKAKDDQTPLHCAARMGHKELVKLLMEHKANPDSATTAGHTPLHIAAREGHAQTTRI S.cerevisiae DIDCRDPKGRTSLLWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKY A.thaliana KDSRNMAGGFYALHCAARRGDVKAVKLLSGKGYSLDIPDGDGYTPLMLAAREGHGHMCEY O.sativa DAIAGQQPSFRPLHYAARIGDTSSLTQLLKMGHDPNAMDEDGYTPLMHAAAAGKLEACRA . * ** *. : * . . *.*** .: *: . H.sapiens LLEKEASQACMTKKGFTPLHVAAKYGKV--RV---------------AELLLERDAHPNA P.troglodytes LLEKEASQACMTKKGFTPLHVAAKYGKV--RV---------------AELLLERDAHPNA M.mulatta LLEKEASQACMTKKGFTPLHVAAKYGKV--RV---------------AELLLEQDAHPNA M.musculus LLEKEASQACMTKKGFTPLHVAAKYGKV--RL---------------AELLLEHDAHPNA B.taurus LLEKEASQTCMTKKGFTPLHVAAKYGKV--RM---------------AELLLEHDAHPNA C.lupus LLEKEASQACMTKKGFTPLHVAAKYGKV--RV---------------AELLLGRDAHPNA G.gallus LLEKGASQTCMTKKGFTPLHVAAKYGKV--DV---------------AELLLVHDAHPNA R.norvegicus LLEKEASQACMTKKGFTPLHVAAKYGKV--RL---------------AELLLEHDAHPNA D.rerio LLDENAQQTKMTKKGFTPLHVACKYGKV--DV---------------VELLLERGANPNA S.cerevisiae LIQDGADFFQKTDTGKDCFAIAQEMNTVYSLREALTHSGFDYHGYPIKKWFKKSQ-HAK- A.thaliana LISCGANCNAKNGRGEKLLD------LATGDA---------------EKVIRNEL----- O.sativa LVSRGGAADAGSETALSVAR---RSGRSNKAT---------------EEWLLDHV----- *:. . . . : : H.sapiens AGKNGLTPLH-------VAVHHNNLDIV-KLLLPR---GGSPHSPAWNGYTPLHIAAKQN P.troglodytes AGKNGLTPLH-------VAVHHNNLDIV-KLLLPR---GGSPHSPAWNGYTPLHIAAKQN M.mulatta AGKNGLTPLH-------VAVHHNNLDIV-KLLLPR---GGSPHSPAWNGYTPLHIAAKQN M.musculus AGKNGLTPLH-------VAVHHNNLDIV-KLLLPR---GGSPHSPAWNGYTPLHIAAKQN B.taurus AGKSGLTPLH-------VAVHHNHLDVV-RLLLPR---GGSPHSPALNGYTPLHIAAKQN C.lupus AGKNGLTPLH-------VAVHHNHLDIV-RLLLPR---GGSPHSPAWNGYTPLHIAAKQN G.gallus AGKNGLTPLH-------VAVHHNNLEIV-KLLLPK---GSSPHSSAWNGYTPLHIAAKQN R.norvegicus AGKNGLTPLH-------VAVHHNNLDIV-QLLLPR---GGSPHSPAWNGYTPLHIAAKQN D.rerio AGKNGLTPLH-------VAVHHNNLDVV-KLLVSK---GGSPHSTARNGYTALHIAAKQN S.cerevisiae -LVTFITPFLFLGIAFALFSHINPLFVIIVLFLLAIATNKGLNKFVLPSYGRMGV--HNV A.thaliana ---------------------------S-RRFVIE---GSSVMKHTKGGKGKKHG--KGL O.sativa ---------------------------A-RAHVLA---GEELTKHTRGGRGPPHR--KAV : . . . : H.sapiens QVEV-------ARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVALLLSKQA-NGNLG P.troglodytes QVEV-------ARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVALLLSKQA-NGNLG M.mulatta QVDV-------ARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVALLLSKQA-NGNLG M.musculus QIEV-------ARSLLQYGGSANAESVQGVTPLHLAA-QEGHTEMVALLLSKQA-NGNLG B.taurus QLEV-------ARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVALLLSKQA-NGNLG C.lupus QMEV-------ARSLLQYGGSANAESVQGVTPLHLAA-QEGHAEMVALLLSKQA-NGNLG G.gallus QMEV-------ASSLLQYGASANAESVQGVTPLHLAS-QEGHTDMVALLFSKQA-NGNLG R.norvegicus QIEV-------ARSLLQYGGSANAESVQGVTPLHLAA-QEGHTEMVALLLSKQA-NGNLG D.rerio QLEV-------ASSLLQYGANANSESLQGITPLHLAS-QEGQPDMVALLISKQA-NVNLG S.cerevisiae TLLRSPLLSGVFFGTLLWVTIVWF---FKVMPRTFSDEQYTNILMLVILVSVFYLFGQLV A.thaliana RMLE-------SSGVLSWGKSRKRTVV---------C-KEVEIGMSQRFRKNRK-GKGDG O.sativa RMMR--------SGVLTWGATRRRNVA---------C-REARAGPSAAFRRNRR-IIRTG : . * : : . : H.sapiens NK-SG-----------------LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH P.troglodytes NK-SG-----------------LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH M.mulatta NK-SG-----------------LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH M.musculus NK-SG-----------------LTPLHLVSQEGHVPVADVLIKHGVTVDATTRMGYTPLH B.taurus NK-SG-----------------LTPLHLVAQEGHIPVADVLIKHGVTVDATTRMGYTPLH C.lupus NK-SG-----------------LTPLHLVAQEGHVPVADVLIKHGVTVDATTRMGYTPLH G.gallus NK-SG-----------------LTPLHLVAQEGHVPVADVLVKHGVTVDATTRMGYTSLH R.norvegicus NK-SG-----------------LTPLHLVAQEGHVPVADVLIKHGVTVDATTRMGYTPLH D.rerio NK-NG-----------------LTPLHLVAQEGHVGIADMLVKQGASVYAASRMGYTPLH S.cerevisiae IMDPGCLPEETDHENVRQTISNLLEIGKF-DTKNFCI-ETWIRKPL------RSKF---- A.thaliana AEEEGIFRVVT---------TENKEVHFVCEGGLVCA-EMWVR-G--------------- O.sativa SEEQLILMVET---------VTGREIHFEATS-ASSV-ELWVR-G--------------- : : :: H.sapiens VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD P.troglodytes VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD M.mulatta VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDVVTLLLKNGASPNEVSSD M.musculus VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSN B.taurus VASHYGNIKLVKFLLQHKADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKHGASPNEVSSN C.lupus VASHYGNIKLVKFLLQHQADVNAKTKQGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSN G.gallus IASHYGNIKLVKFLLQHQADVNAKTKLGYTPLHQAAQQGHTDVVTLLLKHGASPNEISTN R.norvegicus VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSN D.rerio VACHYGNIKMVKFLLQQQAHVNSKTRLGYTPLHQAAQQGHTDIVTLLLKHGALPNEITTN S.cerevisiae -----------------------------SPLNNAVVARFDHYCPWIFND---------- A.thaliana -------IR--------------------------------------------------- O.sativa -------IN--------------------------------------------------- H.sapiens GTTPLAIAKRLGYISVTDVLKVVTDETSFVL--VSDKHRMSFPE----TVDEILDVSEDE P.troglodytes GTTPLAIAKRLGYISVTDVLKVVTDETSFVL--VSDKHRMSFPE----TVDEILDVSEDE M.mulatta GTTPLAIAKRLGYISVTDVLKVVTDETSFVL--VSDKHRMSFPE----TVDEILDVSEDE M.musculus GTTPLAIAKRLGYISVTDVLKVVTDETSVVL--VSDKHRMSYPE----TVDEILDVSEDE B.taurus GTTPLAIAKRLGYISVTDVLKVVTDETTVQL--ITDKHRMSFPE----TVDEILDVSEDE C.lupus GTTPLAIAKRLGYISVTDVLKVVTDEPSFVVSQLLDKHRLSFPE----TVDEILDVSEDE G.gallus GTTPLAIAKRLGYISVTDVLKIVTEETTIP--PFSDKYRMSFPE----TVDEILDVSEDE R.norvegicus GTTPLAIAKRLGYISVTDVLKVVTDETSVVL--VSDKHRMSYPE----TVDEILDVSEDE D.rerio GTSPLGIAKRLGYISVIDVLKLVTEESVSMI--TTEKHRMSFPE----TVDEILDVSEDE S.cerevisiae ----VGLKNHKAFIFFI---------------TLMESGIFTFLALCLEYFDELEDAHEDT A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens GE--------ELISFKAERRDSR-DVDEEKELLDFVP--KLDQVVESPAIPRIPCAMPET P.troglodytes GE--------ELIGFKAERRDSR-DVDEEKELLDFVP--KLDQVVESPAIPRIPCAMPET M.mulatta GTAHITIMGEELIGSKPERPDSR-DVDEEKELLDFVP--KLDQVVESPAIPRIPCVTPET M.musculus GTAHISIMGDELVGSKAERRDSR-DVGEEKELLDFVP--KLDQVVESPAIPRIPCVTPET B.taurus GED---------LGPRAERPDAR-DVDEEKELLDFVP--KLDQVVESPAIPRIPCVTPET C.lupus GEE---------LVSKAEKPDSR-DIDEEKELLDFVP--KLDQVAVQMMCWG---QSKEP G.gallus GTAHVTVMEEELVPPKPRTPEPK-EQEGKREMLEFVTVTTLEQMEESAAVPQVPCVPPET R.norvegicus GTAHISLTGDELVGSKAERRDSR-DVGEEKELLDFVP--KLDQVVESPAIPRIPCVTPET D.rerio GDELLGMDGARYLKLDDLKDQDDDFLSPKKTLRDFES--GMGTTPYSPAIPRIPCVSPET S.cerevisiae SQ----KNGKCFILGAS-------DLCSGLIYDRFVFLILLWALFQSIWVASLIFVQAFQ A.thaliana ------------------------------------------------------LVTRET O.sativa ------------------------------------------------------LIVQDC H.sapiens VVIRSEEQE-----QASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG P.troglodytes VVIRSEEQE-----QASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG M.mulatta VVIRSEEQE-----QASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG M.musculus VVIRSEDQE-----QASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG B.taurus VVIRADEPD-----QVSKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG C.lupus TNKGSEAEK-----QASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG G.gallus VVTIAEESE-----QMGPEFDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG R.norvegicus VVIRSEDQE-----QASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG D.rerio VMLDQHTPV-----PLPKEYDEDSLIPSSPATETSDNVSPVASPIHTGFLVSFMVDARGG S.cerevisiae ICKGMTNTEFNVLMKESKSIGPDGLSFNENFNTTPEGFAPSIDPGEESN-DTVLAPVPGS A.thaliana ICGRTQTQN--------------------------------------------------- O.sativa AWSRPDEAE-----QA-------------------------------------------- H.sapiens SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ P.troglodytes SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ M.mulatta SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ M.musculus SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLNTPPPLAEEEGLASRIIALGPTGAQ B.taurus SMRGSRHNGLRVVVPPRTCAAPTRITCRLVKPQKLPTPPPLAEEEGLASRVIALGPTGVQ C.lupus SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ G.gallus SMRGSRHHGLRVVIPPRACAAPTRITCRLVKPQKLPAPPPLAEEEGLASRIIALGPAGAQ R.norvegicus SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQ D.rerio SMRGSRHNGLRVIIPPRTCAAPTRITCRLVKPQKLTTPPPLVEGEGLASRIISLGPSSMQ S.cerevisiae -----------TIRKPRTCFGVCYA----VT--------------GM-----------DQ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens FLS---------------------------PVIVEIPHFASHGRGDRELVVLRSENGSVW P.troglodytes FLS---------------------------PVIVEIPHFASHGRGDRELVVLRSENGSVW M.mulatta FLS---------------------------PVIVEIPHFASHGRGDRELVVLRSENGSVW M.musculus FLS---------------------------PVIVEIPHFASHGRGDRELVVLRSENGSVW B.taurus FLS---------------------------PVIVEIPHFASQGRGDRELVVLRSENGSVW C.lupus FLRXEVPRVGHACATRVSNLPPPRRRAQGGPVIVEIPHFASHGRGDRELVVLRSENGSVW G.gallus FLS---------------------------PVIVEIPHFASYGRGDRELVVLRSENGSVW R.norvegicus FLS---------------------------PVIVEIPHFASHGRGDRELVVLRSENGSVW D.rerio FLG---------------------------PVIVEIPHFASLSRGDRELVVLRSENGSVW S.cerevisiae WLAVIKETIGIKDSTG----------HNVYSITSRIPTNYGWKRNVKDFWLTSDINAPLW A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG P.troglodytes KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG M.mulatta KEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG M.musculus KEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG B.taurus KEHKNRYGESYLDQILNGMDEELGSLEELEKKRVCRIVTTDFPLYFVIMSRLYQDYDTIG C.lupus KEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDFDTIG G.gallus KEHRNRYEESYMDQLLSGMDEELESQEELEKKRVCRIITTDFPLYFVVMSRICQDCDMIG R.norvegicus KEHKSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIG D.rerio KEHRNRYGDDVLETILNGMDEDLESQEELEKKRIRRIISTDFPLYFAVVSRVRQESDLIG S.cerevisiae RRI--LYPPSGSKALLNGIEVDYFKLYKLPN------------------KDVEQGNDMV- A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR P.troglodytes PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR M.mulatta PEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR M.musculus PEGGSLRSKLVPLVQATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR B.taurus PEGGSLTSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR C.lupus PEGGFLKSKLVPLVMATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR G.gallus PEGGCLKSTLVPMVQATFPDTAVTKKVRLALQAQPVPDELVTKLLGNQATFSPIVTVEPR R.norvegicus PEGGSLRSKLVPLVQATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPR D.rerio PEGGQLASKLVPQVQAIFPDTAVTKRVRLGLQAQPIPDELLTRQLGNQATFSPVVTVEPR S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA P.troglodytes RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA M.mulatta RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA M.musculus RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYA B.taurus RRKFHRPIGLRIPLPPSWMDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYA C.lupus RRKFYRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVTGGTDQAQWEDITGTTKLVYA G.gallus RRKFHRPIGLRIPLPPSWKDNPRDSGEGDTTSLRLLCSVIGGTAQAQWEDITGTTKLVYE R.norvegicus RRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYA D.rerio RRKFHRPIGLRIPLPPSWRESPRDAGEGDTTSLRLLCSVIGGTAPAQWEDITGTTKLMYS S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR P.troglodytes NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR M.mulatta NECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR M.musculus NECANFTTNVSARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDAREGRLR B.taurus NECATFTTNVSARFWLSDCPRTAEAVNFATQLYKELTAVPYMAKFVIFAKMNDLREGRLR C.lupus NECAAFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDSREGRLR G.gallus KECANFTTNVSARFWLADCPRTAEAVHFATVLYKELTAVPYMAKFVVFAKMNDGREGRLR R.norvegicus NECANFTTNVSARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDPREGRLR D.rerio HNCANFTTNVSARFWLADCPRTAEAVTFANLLYRELMSVPYMAKFVVFAKMNDAREGRLR S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQ-QRSFHFQ P.troglodytes CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQ-QRSFHFQ M.mulatta CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQ-QRSFHFQ M.musculus CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQ-QRSFHFQ B.taurus CYCMTDDKVDKTLEHHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQ-QRSFLFQ C.lupus CYCMTDDKVDKTLEQHENFIEVARSRDIEVLEGMPLFAELFGNLVPVKKAAQ-QRSFHFQ G.gallus CYCMTDDKVDKTLEHHENFTEVARSRDIEVVEGMPLHVELSGNLVPVKKATQ-SRTFFFQ R.norvegicus CYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQ-QRSFHFQ D.rerio CYCMTDDKIDKTLELHENFSEVARSRDIEVMEGMPLHLECSGNLVPVRKATQQPRSFSFQ S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens SFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRR P.troglodytes SFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRR M.mulatta SFRENRLAIPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCSKGSGAEDRR M.musculus SFRENRLAIPVKVRDSSREPGGFLSFLRKTMKYEDTQHILCHLNITMPPCTKGSGAEDRR B.taurus SFRENQLAIPVKVRDSSREPAGFLSFLRKAMKYEDTQHILCHLNITMPPCTKDSGADERR C.lupus SFRENRLAIPVKVRDNSREPAGSLSFLRKAMKYEDTQHILCHLNITMPAFVKTIMTDERR G.gallus SFRESRLAIPIKVRDSSREASGSLSFLRKAMKYEDLQHVLCHLNISIPPCTKGSSTEERR R.norvegicus SFRENRLAIPVKVRDSSREPGGFLSFLRKPMKYEDAQHILCHLNVTMPPCTKGSGAEDRR D.rerio AFRDNRLPVSVKVRDANKEASGFLSFLRKSTKYEDTQHVLCNLNITMPPCVKGVGSDDRR S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens RTPTPLALR--YSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINR P.troglodytes RTPTPLALR--YSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINR M.mulatta RTPTPLALR--YSILSESTPGLLSGTDQAE-KMAVISEHLGLSWAELARELQFSVEDINR M.musculus RTLTPLTLR--YSILSESRLGFTSDTDRVEMRMAVIREHLGLSWAELARELQFSVEDINR B.taurus RTLTPLALR--YSLLE-STADFLSGTDQADMKMMLISEHLGLSWAELARELQFSVDDINR C.lupus RTLTPLALR--YSILSESSLGFLSGTDRADMKMAIISEHLGLSWAELARELQFSVEDINR G.gallus RTLTPLSLREXYSILSESSFGSLSSTDRADQKMIDIAEQLGLSWAELARELQFGVDDINR R.norvegicus RTLTPLTLR--YSILSESRLGFTSDTDRVEMKMAVIREHLGLSWA--------------- D.rerio RTLTPLALRERYSALSEPGLAAVNAMERTELKITVIAEQLGLSWTELARELQFGVDDINR S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens IRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRN-- P.troglodytes IRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRN-- M.mulatta IRVENPNSLLEQSVALLNLWVIREGQNTDMENLCTALQSIDRGEIVNMLEGSGRQSRN-- M.musculus IRVENPNSLLDQSTALLTLWVDREGENAKMENLYTALRNIDRSEIVNMLEGSGRQSRN-- B.taurus IRVENPNSLLEQSLALLNLWVTREGQDAKMENLYAALRNIDRGEIVNMLEGSGRQGRS-- C.lupus IRVENPNSLLEQSAALLNLWVLREGKNANMENLYAALRNIDRSEIVNMLEGSGRQSRN-- G.gallus IRVENPNSLLEQSIALLNLWVSREGKGVKIENLYTALRNIDRSEIISTLEGSGRQSRS-- R.norvegicus -----------------------------VENLYTALRNIDRSEIVNMLEGSGRQSRN-- D.rerio IRVENPNSLLDQSSALLNLWVGREGKKAKMESLYGALKNIDRSDIVKCLEAQAPPVLPET S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens -LKPDRRHTDRD-YSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAI P.troglodytes -LKPDRRHTDRD-YSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAI M.mulatta -LKPDRRHTDRD-YSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAI M.musculus -LKPERRHGDRE-YSLSPSQVNGYSSLQDELLSPASLQYALPSPLCADQYWNEVAVIDAI B.taurus -LKPDRRPADRD-YSSSPSQMNGYSSLQDELLSPASLHYALPSPLRADQYWNEVAVLDAI C.lupus -LKPERRHTDRD-YSSSPSQMNGYSSLQDELLSPASLHYALPSPLRADQYWNEVSVIDAI G.gallus -MKGSWRYMDRD-YSLSPSQMNGYASLQDELLSPASLHYMLPSPLRADQYWNEVAIMDAI R.norvegicus -LKPDRRHGDRE-YSLSPSQVNGYSSLQDELLSPASLHYALPSPLCADQYWNEVAVIDAI D.rerio LEEGACRLVDRDSTLLSPSVVNGYGLVQEELLSPASMQYSLPSPLGVEPYWQEVSSLECA S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens PLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEP P.troglodytes PLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEP M.mulatta PLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEP M.musculus PLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDAI-PEWKLEGAHSEDT B.taurus PLAGTEHDALLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEGP C.lupus PLAATEHDAMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKPEGVLSEEP G.gallus PMAATEQDALMEMSDMQVWSSGLTPSLVTAEDSSLECSKAEDSDATSEGRFPGHLLTDAH R.norvegicus PLAATEHDTMLEMSDMQVWSSGLTPSLVTAEDSSLECSKAEDSDAI-PEWKLEGAHSEDT D.rerio PIATTEEDTMLEMSDVQVWPAGVSPSLVTVEDSSLDGSSRADDSEGNTLSLPCSSLGRPS S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens ---RGPELGSLELVEDDT---VDSD-----ATN---------G---LIDLLEQEEGQRSE P.troglodytes ---RGPELGSLELVEDDT---VDSD-----ATN---------G---LIDLLEQEEGQRSE M.mulatta ---RGPELGSLELVEDDT---VDSD-----ATN---------G---LIDLLEQEEGQRSE M.musculus ---QGPELGSQDLVEDDT---VDSD-----ATN---------G---LADLLGQEEGQRSE B.taurus ---QGPTLGSLDLVEDDT---VDSD-----ATN---------G---LIDLLDQEEGQRSE C.lupus ---QGPTLGSLDLVEDDT---VDSD-----ATN---------G---LIDLLDQEEGQRSE G.gallus ---VPDHMGSMDLVEDDT---VDSD-----AMN---------G---LIELLEQEEGQRPE R.norvegicus ---QGPELGSQDLVEDDT---VDSD-----ATN---------G---LADLLGQ------- D.rerio SGASGASGSIMELEEEEEEEEIEEDDIQHEPVSASAEKAWASGAVPKANYNGQAGGQRSE S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens EKLPGSK---------RQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVS-------- P.troglodytes EKLPGSK---------RQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVS-------- M.mulatta EKLPGSK---------RQDDATGAGQDSENEVSLVSGHQRGQARQKSSVGRSGEGGAFPR M.musculus KK---------------RQEVSGTEQDTETEVSLVSGQQRVHARITDSPSVR-------- B.taurus EKLPGHE---------RQEDSTGAGQDSEREVSLVSGQQRVHARVSETPTVS-------- C.lupus EKLPGPK---------RQEDSTGAGQDSENEVSLVSGQQRVQAHITESPSVS-------- G.gallus GKMPASD---------HQLG--TGEQNPESEVSFVSVQQKVQATIVPSPTVS-------- R.norvegicus --------------------------------------QRVHARITDSPSVR-------- D.rerio GKRTDAAAGSSMTSVARGGGKGGKGASSEEKFSVLTGQQL-----------------YAQ S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens -------------------------------------------QVTERSQDRLQDWDADG P.troglodytes -------------------------------------------QVTERSQDRLQDWDADG M.mulatta HCESAAQGRLTLELSSSHLGQGLHYAPLLSAGKDAKASQALAVTERDETDMRLQDWDPDG M.musculus -------------------------------------------QVLDRSQARTLDWDKQG B.taurus -------------------------------------------WAMDSSQDRVHDWDAEG C.lupus -------------------------------------------RVMEPSQERLQDCNEEG G.gallus -------------------------------------------HTVERSADRLRDWNAEG R.norvegicus -------------------------------------------QVLDRSQARTVDWYKQG D.rerio LCERTG---------------------------------------LTRSLEHNGDRLGSG S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens SIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGS--QEYEKVLVSV-------- P.troglodytes SIVSYLQDAAQGSWQEEVTQGPHSFQGTSTTTEGLEPGGS--QEYEKVLVSV-------- M.mulatta SIVSYLQDAAQGSWREEVTQDPHLFQRTSTTTEGLEPSGS--QESENVLVSV-------- M.musculus STAVHPQEATQSSWQEEVTQGPHSFQRRITTIQGPEPGAL--QEYEQVLVST-------- B.taurus SIVSYLQEAAHGSRLEEAPLGPHLFQRTVGGSPELEEGPG--PAAEQSEVGRE-----QR C.lupus SIVSYLQDAAQGFWQEEVTQGPPSFQSTVTTIQELEPSGS--QEHKKVLVSA-------- G.gallus SFISCLQDLTEGSWQEGVTRRLGPAHTVAAGAQGQEQEQVLAPDVELMRVSSTEDSDWQP R.norvegicus SAASYPQEAAQSSWQEEVTQGPQSFQRRITTIQGPEPGTL--QEYEQVVVSTR------- D.rerio AFQPYSQEK-------------------------------------------DSLHSWSQ S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens --SEHTWTEQPE-------------------AE----SSQADR-D-----------R--- P.troglodytes --SEHTWTEQPE-------------------AE----SSQADR-D-----------R--- M.mulatta --SEHTRTEQPE-------------------AE----SSQADR-D-----------Q--- M.musculus --REHVQRGPPE-------------------TG----SPKAGK----------------- B.taurus PPSPQEWTQEAGSTVSLQTQVCA-----PRVLG----TTPHKSLSGLGFAL---EAW--- C.lupus --SEHFWEEQPE-------------------AE----STPADR-E-----------R--- G.gallus QHPAGGWPEEPDSRCFGQSHDFDRSSRVTAVLAETGCVRTCGQLLCPGLCLTQRTAWLGT R.norvegicus ---EHVQRGPPESDS-----------------------PK-------------------- D.rerio PKPRQTMETMMSS-----SPDHNQSRVAQEALLTPVCDTGHSEVL--------RGRLLG- S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens --------RQQGQEEQV------------------------------------------- P.troglodytes --------RQQGQEEQV------------------------------------------- M.mulatta --------RQQGQGEQV------------------------------------------- M.musculus -------------EPSL------------------------------------------- B.taurus --------AGEQSRMWTFVTQLLVTLVLLGFFLVSCQNVAHIVRGSLGFMLKHVHQELDK C.lupus --------RRQSHLEWV------------------------------------------- G.gallus EQGCRAPARPCRGRMWSFLVQLLIVVVLLAFFLVSCQNVLYIVRGSVRFLLNHAHRELDK R.norvegicus ------------------------------------------------------------ D.rerio ------------------------------------------------------TQPFDK S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens ---------------QEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKV P.troglodytes ---------------QEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKV M.mulatta ---------------QEARNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKV M.musculus ---------------WAPESAFSQEVQGDELQNIPGEQVTEEQFTDEQGNIVTKKIIRKV B.taurus ELGESEGLSDDEETISTRVVRRRVLLKGNELQNIPGEQVTEEHFTDEQGNVITKKIVRKV C.lupus ---------------QEAQSTFSQMAESERVS-VQGHQTN--AFQKRH------SLIRKV G.gallus ELGESQGLADDEESLSTRVVRRRVLVKGNEVLHLPGEHVTEEQFTDEQGNIITKKVIRKV R.norvegicus --------AGKDPSLWASESAFSQEVQGDELQNIPGEQVTEEQFTDEQGNIVTKKIIRKV D.rerio GLGF----SHQEGELRAWD-QERRKAQKDDPVDLSSDLLHEEQFTDEHGNVVTKLGVDVK S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens --VRQIDLSSADAAQE-----HEEVELRGSGLQPDLIEGRKGAQIVKRA----------- P.troglodytes --VRQIDLSSADAAQE-----HEEVELRGSGLQPDLIEGRKGAQIVKRA----------- M.mulatta --VRQIDLSSADAAQE-----HEEDHTSTPNP---------------------------- M.musculus --VRQVDSSGAID--TQQ---HEEVELRGSGLQPDLIEGRKGAQIVKRA----------- B.taurus --VRQIDPSGADD--TQE---LEEVELRGSGLQPDLIEGRKGAQIVKRA----------- C.lupus ---RFLGPQAATTAFVNQ---LCKGEPRACRPAPG----R-------------------- G.gallus --VHQLDLDTDDRKEHEE---DLTST-------PNH------------------------ R.norvegicus --VRQVDSSGAID--TQQ---HEEVELRGSGLQPDLIEGRKGAQIVKRA----------- D.rerio KDVQTVKRSSLRRGRTSTAKSSFTYARLGDRTRHRAMGGKNNMQRKKNTSQPNPTVKQPQ S.cerevisiae ------------------------------------------------------------ A.thaliana ------------------------------------------------------------ O.sativa ------------------------------------------------------------ H.sapiens SLKRGKQ------- P.troglodytes SLKRGKQ------- M.mulatta -------------- M.musculus SLKRGKQ------- B.taurus SLKRGKQ------- C.lupus -------------- G.gallus -------------- R.norvegicus SLKRGKQ------- D.rerio RVTRKQQGEGVLYL S.cerevisiae -------------- A.thaliana -------------- O.sativa --------------